Neonatal Brain Hemorrhage: The Role of NonProtein-Bound Iron

Serafina Perrone; Simona Negro; Maria Luisa Tataranno; Antonino Santacroce; Carlotta Bracciali; Mariangela Longini; Fabrizio Proietti; Francesco Bazzini; Elisa Belvisi; Giuseppe Buonocore; on behalf of the “Gruppo di Studio di Biochimica Clinica Neonatale della Società Italiana di Neonatologia”

doi:10.1055/s-0036-1593755

Journal of Pediatric Biochemistry, Table of Contents

Journal of Pediatric Biochemistry 2016; 06(02): 88-91
DOI: 10.1055/s-0036-1593755

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Neonatal Brain Hemorrhage: The Role of NonProtein-Bound Iron

Serafina Perrone

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Simona Negro

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Maria Luisa Tataranno

²Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands

,

Antonino Santacroce

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Carlotta Bracciali

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Mariangela Longini

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

³Clinical Pathology, AOUS Siena, Italy

,

Fabrizio Proietti

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Francesco Bazzini

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Elisa Belvisi

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Giuseppe Buonocore

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

on behalf of the “Gruppo di Studio di Biochimica Clinica Neonatale della Società Italiana di Neonatologia”

› Author Affiliations

Abstract

Intraventricular hemorrhage (IVH) in very preterm infants is a common disease, which can induce long-term consequences. Oxidative stress (OS) occurs easily in preterm newborns due to an imbalance between high free radical (FR) production and the low antioxidant shield, not completely developed at birth. Nonprotein-bound iron (NPBI) concentration in cord blood has been found to be highly predictive for the risk of poor neurodevelopmental outcome. However, at present, no data exist about the exact mechanisms associated with IVH induced by iron-mediated FRs. We propose the hypothesis that hypoxia or ischemia-induced releasing of NPBI is a key regulating event that initiates a vicious circle of excessive FR generation, which in turn participates in edema development, inflammatory reaction, and endothelial injury. This suggests that developing effective neuroprotective strategies for preterm infants requires a detailed understanding of OS reactions and glial responses.

Keywords

intraventricular hemorrhage - nonprotein-bound iron - oxidative stress - free radicals

Full Text

References

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